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KMID : 0616120060370030157
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Korean Journal of Pharmacognosy
2006 Volume.37 No. 3 p.157 ~ p.161
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Inhibitory Activity on Monoamine Oxidase of Prunella vulgaris
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Hwang Keum-Hee
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Abstract
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We examined the inhibitory activities against monoamine oxidase (MAO) of Prunella vulgaris in vitro and in vivo methods. Methanolic extrac of P. vulgaris showed significantly inhibitory activites on MAO-A and MAO-B that were prepared from rat brain and liver in vitro. The inhibitory activities were measured by serotonin and benzylamine as substrates, respectively. MAO-A and MAO-B activities were potently inhibited by ethylacetate extracts of P. vulgaris in vivo tests. It was observed that those activities in vivo tests have different tendency each other. MAO-A activity was increased by the oral administration of methanolic extract of P. vulgaris, while MAO-B activity was decreased. Consequently, we suggest that P. vulgaris may have the effects on the inhibitory activities against MAO both in vitro and in vivo.
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KEYWORD
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monoamine oxidase (MAO), serotonin (5-HT), Prunella vulgaris,
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